Endocrine Abstracts

The term “hyperthyroidism” is a form of thyrotoxicosis due to inappropriately high synthesis and secretion of thyroid hormone(s) by the thyroid. The leading cause of hyperthyroidism in adolescents is Graves’ disease; however, one should also consider other potential reasons such as toxic adenoma (TA) or a toxic multinodular goiter (TMNG), and other rare disorders leading to excessive production and release of thyroid hormones. The term “thyrotoxicosis&#...

Introduction: Hashimoto’s thyroiditis (HT) and Graves' disease (GD) constitute a spectrum of autoimmune thyroid diseases (AITD). An abnormal thyroid echographic pattern characterized by a diffuse low echogenicity has been described in both AITD. This hypoechogenicity is due to three components: increase of intrathyroidal flow, functional changes in thyroid follicles with increased cellularity and decrease of the colloid content, resulting in the reduction of the cell/coll...

Puberty is a process in humans that leads to the development of secondary sexual characteristics and reproductive capabilities. The physical changes of puberty result from two separate and independent but overlapping processes: gonadarche and adrenarche. The activation of hypothalamic-pituitary-gonadal (HPG) axis plays a key role in gonadarche whereas body weight and body mass index are postulated as triggering the adrenarche. The impairment of this cascade will result in temp...

Introduction: The HECa10 line was derived from the specialized endothelial cells typically occurring in lymphoid tissues and belonging to high endothelial vessels (HEVs). Recent studies have shown that HEVs are also present within the tumor microenvironment, what unlike to other blood vessels, can be associated with favorable prognosis of cancer patients. Estradiol (E2) and its metabolite 2-methoxyestradiol (2ME2) are known as the important modulators of cardiovascular system ...

Apoptosis is an important process influencing tissues growth, however the assessment of this process in monolayer culture is difficult because apoptotic cells disappear quickly due to secondary necrosis. Most of the methods used with success in vivo is useless in vitro. Our approach to evaluating apoptosis in vitro is based on the possibility to perform multiple assays on the same sample well. The aim of the study was to evaluate the effect of mifepristone (RU-486), a...

Introduction: In case of isolated adrenal metastases, complete surgical resection of the disease is a potentially curative treatment. Minimally invasive adrenalectomy is recommended in most patients with focal adrenal lesions without evidence of local invasion. However, data on surgical outcomes and survival after laparoscopic adrenalectomy (LA) for adrenal metastases are still lacking to clearly define the role of this procedure in the management of metastatic disease. <p...

Introduction: 18F- Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (18F-PSMA PET/CT) is currently used in the evaluation of prostate cancer. Due to increased expression of PSMA in the neovascular endothelial cells of malignant lesions other than prostate cancer, PSMA PET/CT has become of interest to researchers in the management of thyroid cancer. The goal of this study was to evaluate the incidence and clinical signifi...

Introduction: In the etiology of thyroid dysgenesis (TD) an interplay between genetic and environmental factors is thought to play a crucial role. Data from previous studies on association between the season of birth and the incidence of TD causing congenital hypothyroidism (mainly agenesis and ectopy) are conflicting. To date, seasonality of births have not been analysed yet in regard to congenital absence of one thyroid lobe (thyroid hemiagenesis, THA).<p class="abstext"...

Introduction: Kearns-Sayre syndrome (KSS) is a rare mitochondrial cytopathy. The diagnosis of KSS is made on the classical triad of symptoms: onset of the disease <20 years of age, progressive external ophthalmoplegia (PEO) and pigmentary retinopathy (PR). KSS is manifested also by other systemic abnormalities: cardiac conduction defects, different neurological abnormalities and several endocrine disorders. A variety of deletions and/or duplications in mtDNA, affecting gen...

Introduction: In years 1996–2000, the predominance of papillary thyroid carcinoma (PTC) (70.3%) compared to follicular thyroid carcinoma (FTC; 27.0%) and medullary thyroid carcinoma (MTC; 2.7%) was observed in our region. AIT coexisted in 1 PTC (2.7% of all cancers and 3.8% in PTC group).Aim: The aim of retrospective study was to analyze the coexistence of AIT and TC in years 2001-2015 in relation to years 1996–2000.Mater...